I am Chenkai Guo (郭臣凯), a third-year MS student at Prof.Guangdun Peng (彭广敦)’s Lab at Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS). Previously, I obtained B.S. in College of Life Sciences from South China Agricultural University (SCAU). My research interests focuses on developing AI/ML algorithms for single-cell and spatial omics. During my spare time, I enjoy playing billards and listening to EDM music.
Feel free to reach out to me via email or WeChat at any time. I’m always happy to connect.
🔥 Recent News
- October 2025: I am honored to obtain the National Scholarship in China.
- August 2025: SPHENIC preprint is now available on arXiv now.
- February 2025: 🎉🎉 PASSAGE is accepted by Small Methods as a cover story.
- September 2024: PASSAGE preprint is now available on bioRxiv now.
- July 2023: New journey at GIBH, CAS.
📝 Selected Publications
(*: equal contribution, ✉: corresponding authors)
SPHENIC: Topology-Aware Multi-View Clustering for Spatial Transcriptomics Chenkai Guo, Yikai Zhu, Renxiang Guan, Jinli Ma, Siwei Wang, Ke Liang, Guangdun Peng, Dayu Hu ✉
Keywords
- Persistent Homology;
- Multi-view Clustering;
- Graph Learning;
Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE Chen-Kai Guo*, Chen-Rui Xia*, Guangdun Peng✉, Zhi-Jie Cao✉, Ge Gao✉
Keywords
- Multi-slice Spatial Analysis;
- Graph Attention Network;
- Contrastive Learning;
🎓 Educations
Chinese Academy of Sciences
M.S. student in Cellular Biology, in Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), advised by Prof. Guangdun Peng. 2023.09 - present
South China Agritural University
B.S. in National Scientific Base of Life Sciences, College of Life Sciences, advised by Prof. Guohui Zhu, Prof. Faqiang Li, and Prof. Mei Hong. 2019.09 - 2023.06
💻 Internships
Peking University
Visiting student, Biomedical Pioneering Innovation Center(BIOPIC), Peking University, advised by Prof.Ge Gao, focus on deep learning algorithm development of spatial transcriptomics. 2023.09 - 2024.09
Guangzhou Institutes of Biomedicine and Health
Undergraduate Innovation and Entrepreneurship Training Program, in Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), advised by Prof. Guangdun Peng. 2022.08 - 2023.08
Shanghai Jiao Tong University
Internship, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, advised by Prof.Ilya A. Vinnikov. 2021.07 - 2021.09
🎖 Honors and Awards
- October 2025, National Scholarship in China
- October 2025, Outstanding Poster Award (second prize) in the 14th National Conference on Bioinformatics and Systems Biology
- May 2025, Pacemaker to Merit Student
- May 2025, Second Prize Scholarship
- December 2024, Outstanding Poster Award in Graduate Academic Forum at GIBH
- September 2023, Global Gold Medal of iGEM competition (Advisor)
- June 2023, Outstanding Undergraduate Student of SCAU
- November 2022, First Prize Scholarship
- September 2021, Global Gold Medal of iGEM competition (Drylab member)
💬 Talks
- January 2026, Decoding Spatial Heterogeneity: From Phenotyping Signatures to Topology-Aware Clustering, 22nd SINH Graduate Academic Forum
- July 2025, Exploring Phenotype Associated Signatures in Multiple Spatial Transcriptomic Slices, GIBH Graduate Academic Forum
- May 2025, Exploring Phenotype Associated Signatures in Multiple Spatial Transcriptomic Slices, The 2nd GIBH Youth Forum
🔗 Cooperators
I am deeply grateful to all the colleagues I have had the honor of collaborating with, both in the past and presently.
SPHENIC project:
- Prof. Dayu Hu (College of Medicine and Biological Information Engineering, Northeastern University)
PASSAGE project:
- Prof. Ge Gao (BIOPIC, Peking University)
- Dr. Zhi-Jie Cao (BIOPIC, Peking University)
- Dr. Chen-Rui Xia (BIOPIC, Peking University)
Career in Penglab:
- Prof. Guizhong Cui (Guangzhou Laboratory)
- Prof. Dongye Wang (GIBH, Chinese Academy of Sciences)
- Prof. Guangyu Zhang (Chongqing Medical University)
- Prof. Ying Chen (Yangzhou University)
- Dr. Mingyue Guo (University of Pennsylvania)
- Dr. Xiaogao Meng (Guangzhou Laboratory)
- Dr. Yao Yao (GIBH, Chinese Academy of Sciences)
- Dr. Jincan Ke (GIBH, Chinese Academy of Sciences)
- Dr. Haoxian Wang (GIBH, Chinese Academy of Sciences)