I am Chenkai Guo (郭臣凯), a third-year MS student at Prof.Guangdun Peng (彭广敦)’s Lab at Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS). Previously, I obtained B.S. in College of Life Sciences from South China Agricultural University (SCAU). My research interests focuses on developing AI/ML algorithms for single-cell and spatial omics. During my spare time, I enjoy playing billards and computer games.
Feel free to reach out to me via email or WeChat at any time. I’m always happy to connect.
🔥 Recent News
- August 2025: SPHENIC preprint is now available on arXiv now.
- February 2025: 🎉🎉 PASSAGE is accepted by Small Methods as a cover story.
- September 2024: PASSAGE preprint is now available on bioRxiv now.
- July 2023: New journey at GIBH, CAS.
📝 Publications
(*: equal contribution, ✉: corresponding authors)
SPHENIC: Topology-Informed Multi-View Clustering for Spatial Transcriptomics Chenkai Guo, Yikai Zhu, Jing Yangum, Renxiang Guan, Por Lip Yee, Guangdun Peng✉, Dayu Hu ✉
Keywords
- Persistent Homology;
- Multi-view Clustering;
- Graph Learning;
Learning Phenotype Associated Signature in Spatial Transcriptomics with PASSAGE Chen-Kai Guo*, Chen-Rui Xia*, Guangdun Peng✉, Zhi-Jie Cao✉, Ge Gao✉
Keywords
- Multi-slice Spatial Analysis;
- Graph Attention Network;
- Contrastive Learning;
Jincan Ke, Jian Xu, Jia Liu, Yumeng Yang, Chenkai Guo, Bingbing Xie, Guizhong Cui, Guangdun Peng✉, and Shengbao Suo✉. “High-resolution mapping of single cells in spatial context.” Nature Communications 16, no. 1 (2025): 6533.
Xiaogao Meng*, Wenjia Li*, Jian Xu, Yao Yao, An Gong, Yumeng Yang, Fangfang Qu, Chenkai Guo, Hui Zheng, Guizhong Cui✉, Shengbao Suo✉, Guangdun Peng✉. “Spatiotemporal transcriptome atlas of developing mouse lung.” Science Bulletin (2025).
Nicola Murgia*, Yuan Ma*, Syeda Sadia Najam*, Yu Liu, Joanna Przybys, Chenkai Guo, Witold Konopka, and Ilya A. Vinnikov✉. “In vivo reductionist approach identifies miR-15a protecting mice from obesity.” Frontiers in Endocrinology 13 (2022): 867929.
📖 Educations
Chinese Academy of Sciences
M.S. student in Cellular Biology, in Guangzhou Institutes of Biomedicine and Health (GIBH), Chinese Academy of Sciences (CAS), advised by Prof. Guangdun Peng. 2023.09 - present
South China Agritural University
B.S. in National Scientific Base of Life Sciences, College of Life Sciences, advised by Prof. Guohui Zhu, Prof. Faqiang Li, and Prof. Mei Hong. 2019.09 - 2023.06
💻 Internships
Peking University
Visiting student, Biomedical Pioneering Innovation Center(BIOPIC), Peking University, advised by Prof.Ge Gao. 2023.09 - 2024.09
Shanghai Jiao Tong University
Internship, School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, advised by Prof.Ilya A. Vinnikov. 2021.07 - 2021.09
🎖 Honors and Awards
- May 2025, Pacemaker to Merit Student
- May 2025, Second Prize Scholarship
- December 2024, Outstanding Poster Award in Graduate Academic Forum at GIBH
- September 2023, Global Gold Medal of iGEM competition (Advisor)
- June 2023, Outstanding Undergraduate Student of SCAU
- November 2022, First Prize Scholarship
- September 2021, Global Gold Medal of iGEM competition (Drylab member)
💬 Talks
- July 2025, Exploring Phenotype Associated Signatures in Multiple Spatial Transcriptomic Slices, GIBH Graduate Academic Forum
- May 2025, Exploring Phenotype Associated Signatures in Multiple Spatial Transcriptomic Slices, The 2nd GIBH Youth Forum
🔗 Cooperators
I am deeply grateful to all the colleagues I have had the honor of collaborating with, both in the past and presently.
SPHENIC project:
- Lecturer. Dayu Hu (College of Medicine and Biological Information Engineering, Northeastern University)
- Prof. Por Lip Yee (Department of Computer System and Technology, University of Malaya)
PASSAGE project:
- Prof. Ge Gao (BIOPIC, Peking University)
- Dr. Zhijie Cao (BIOPIC, Peking University)
- Dr. Chenrui Xia (BIOPIC, Peking University)
Career in Penglab:
- Prof. Guizhong Cui (Guangzhou Laboratory)
- Prof. Dongye Wang (GIBH, Chinese Academy of Sciences)
- Prof. Guangyu Zhang (Chongqing Medical University)
- Prof. Ying Chen (Yangzhou University)
- Dr. Xiaogao Meng (Guangzhou Laboratory)
- Dr. Yao Yao (GIBH, Chinese Academy of Sciences)
- Dr. Jincan Ke (GIBH, Chinese Academy of Sciences)
- Dr. Haoxian Wang (GIBH, Chinese Academy of Sciences)